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Anxiety and Depression - Mental Health Frequently Asked Questions F.A.Q.

Anxiety and Depression - Mental Health Questions

How is Depression Treated?
What is Antidepressant Medication?
What is a Neurotransmitter?
What are MAOI Antidepressants?
What are Tricyclic Antidepressants?
What is an SSRI?
Those Side Effect Sound Worrying?
So Should I Quit Taking Antidepressants?
What Can I Do About Sexual Dysfunction?
What Can I Do About a Dry Mouth?
What are Novel Action Antidepressants?
Are Other Neurotransmitters Under Consideration?
Are Any Companies Considering Non-Neurotransmitter Treatment?
What Should I Expect from My Antidepressants?
What Does "Unbearably Severe" Mean?
I Stopped Taking Antidepressants 8 Weeks Ago - Now What Happens?

Anxiety and Depression - Mental Health Answers

How is Depression Treated?

The best choice for treating depression is often a combination of treatments, which include talking therapies, medical treatments, lifestyle choices, and natural treatments. It is possible to cure depression with just one of these treatments, such as therapy, pharmaceutical antidepressants, or lifestyle choices but it is much less likely to work in the long term.

Using a combination of treatments for depression gives you the best chance of successfully eliminating the depression. Medical treatments include antidepressants, shock therapy or ECT and some newer, experimental techniques. Complementary therapies include natural substances like omega-3, SAM-e and St John's Wort. Talking therapies are designed to substitute negative thought and behavior patterns for better ones. Lifestyle choices include exercise, diet, sleep, peer support, and spiritual options.

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What is Antidepressant Medication?

Antidepressants are a type of medication used to relieve the symptoms of depression. There are three main types of antidepressants, which are SSRIs, MAIOs, and tricyclics. There are also others that are referred to as working with novel actions. All antidepressants, no matter what kind they are, work by enhancing at least one of three neurotransmitters in the brain.

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What is a Neurotransmitter?

A neurotransmitter is made out of molecules, which deliver packets of information between neurons across a narrow gap called a synapse. Receptors on the receiving cell get these information packets. The presynaptic neuron releases a wave of neurotransmitters and sends them to the postsynaptic neuron.

Then the presynaptic neuron removes any remain neurotransmitters in the synapse to make room for the next wave of neurotransmitters. There are two kinds of antidepressants that work by blocking the reuptake action. This keeps the neurotransmitters circulating all the time.

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What are MAOI Antidepressants?

MAOIs, nor monoamine oxidase inhibitors, are an older type of antidepressant. The best-known MAOIs are Parnate (tranylcypromine) and Nardil (phenelzine). These work by blocking the monoamine oxidase enzyme, which allows the neurotransmitters to carry out their usual functions.

These drugs are not prescribed as much as some other types because they can have quite bad side effects, including dietary restrictions because of the risk of hypertension. Some psychiatrists consider that these drugs work very well for atypical depression EMSAN (selegiline) has recently been launched by Somerset Pharmaceuticals and this is a transdermal patch that does not have he MAOI side effects.

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What are Tricyclic Antidepressants?

Tricyclics, or TCAs, are older depression drugs that block the absorption by the neuron, or reuptake, of the serotonin and norepinephrine neurotransmitters. Pamelor (nortriptyline) and Elavil (imipramine) are two of the most popular. The side effects can be as bad as with MAOIs but some psychiatrists believe they might be more potent than single action SSRIs because they work with equal force on two neurotransmitters.

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What is an SSRI?

SSRIs, or selective serotonin reuptake inhibitors, block the absorption of serotonin, which is a neurotransmitter. Prozan (fluoxetine), Paxil (paroxetine), Zoloft (sertraline), Luvox (fluvoxamine), Lexapro (escitalopram) and Celexa (citalopram) are examples of SSRI antidepressant drugs.

These drugs have received plenty of hype but they are no more effective than MAOIs or tricyclics. SSRIs have fewer side effects however but the side effects they might have include drowsiness, a dry mouth, weight gain, sexual dysfunction, and disturbed REM sleep.

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Those Side Effect Sound Worrying?

Most of the side effects are temporary so unless they pose a risk to your health or are unbearable, you should allow your body time to adjust. Some side effects might be inconvenient but the antidepressant might be worth them. Bad side effects however should not be part of the price of improving your mood.

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So Should I Quit Taking Antidepressants?

The first step is to notify your psychiatrist or doctor if you are experiencing, bad side effects. He or she might alter your doses or try a different type of antidepressant.

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What Can I Do About Sexual Dysfunction?

For many men and women, Viagra is useful in the case of sexual dysfunction. It might help to switch to Remeron or Wellbutrin or to lower the dosage of your current antidepressant.

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What Can I Do About a Dry Mouth?

Good dental hygiene is important if you are suffering from a dry mouth and drinking a lot of water helps too.

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What are Novel Action Antidepressants?

Novel action antidepressants include Serzone (nefazadone), Effexor (venlafaxine), Wellbutrin (buproprion), Desyrel (trazadone), Cymbalta (duloxetine) and Remeron (mirtazapine). The newest is Cymbalta, which gives similar results to tricyclics and operates on norepinephrine and serotonin.

Effexor is older and Desyrel is older than Effexor. These have a weak norepinephrine action but a strong serotonin action. The other novel action antidepressants work on various neurotransmitters via unique mechanisms. The side effects are like SSRI side effects. Wellbutrin and Remeron cause the least amount of sexual dysfunction.

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Are Other Neurotransmitters Under Consideration?

Yes but they have not been successful. Substance P was a disappointment.

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Are Any Companies Considering Non-Neurotransmitter Treatment?

Some companies are thinking about neuron rather than neurotransmitters. Neurotransmitters live outside neurons, which is why a lot of treatments directed at the neurotransmitters cause side effects and have limited efficacy. There is a variety of chemical processes inside each neuron.

There are no drugs directed at the neurons, which are ready yet. There might be a new drug, which targets the CRF hormone. CRF secretes the stress hormone cortisol and this hormone is thought to be linked to depression. Some companies are currently developing CRF drugs and in the future companies might also investigate gene technology in their antidepressants.

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What Should I Expect from My Antidepressants?

Perhaps the most important advice is not to expect your antidepressants to miraculously cure you overnight. It often takes at least a couple of weeks for the first benefits to be felt and up to a couple of months for the full effect to become apparent. The side effects, on the other hand, often strike you immediately after starting on the antidepressants.

Some side effects such as heightened anxiety usually disappear after a week or so. The first few weeks taking antidepressants will test your patients. Your depression will get you down and the side effects from the pills will seem to make you feel worse rather than better. Unless you are experiencing unbearably severe side effects, you should give your new antidepressants six to eight weeks at least in which to work.

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What Does "Unbearably Severe" Mean?

Most new antidepressants bear warning labels, which explain the possibility of akathisia, which is kind of mental agitation. This is a rare side effect and can make you feel like you are crawling out of your skin. Another possible side effect can happen when a bipolar patient has been diagnosed as having clinical depression.

The antidepressant in this case might bring on a manic episode. Bipolar patients can take antidepressants but normally need mood stabilizing medication too. If you feel hyperactive and not yourself, it is a good idea to stop taking the pills and see your psychiatrist or doctor as soon as you can.

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I Stopped Taking Antidepressants 8 Weeks Ago - Now What Happens?

Many people find that the first antidepressant they are prescribed does not work. No two depressions are alike and neither are two people. A medication might work well for one person but have no positive effect on another. There is a 50/50 chance of a patient responding well to their initial depressant, as demonstrated by studies.

Another result of these studies is that these odds improve when the patient is tried on a second antidepressant. Different treatment guidelines, including those by the American Psychiatric Association, anticipate an initial failure and suggest that the patient should keep trying. If one class of antidepressants does not work, the guidelines suggest trying another class.

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